Preparation of a Bilayer Coating of nHydroxyapatite/Poly(lactic-co-glycolic)acid on Mg and Investigation of Corrosion Properties and Biocompatibility

Document Type : Original Articles

Authors

School of Metallurgy and Materials Engineering, Iran University of science and Technology, Tehran, Iran.

Abstract

In this study, intending to control the corrosion of magnesium and its clinical application, a double-layer coating of Hydroxyapatite- Poly lactic-co-glycolic acid was applied on Mg by means of the electrodeposition and the dip method, respectively. X-ray diffraction (XRD) and scanning electron microscopy (SEM) are used to characterize the phase and morphology of the coatings. The results show a homogeneous coating with a thickness of 20-30 µm. Potentiodynamic polarization of the samples revealed that the double-layer coating exhibited a significant increase in corrosion potential, ranging from -1.82 to -1.4 V, and a decrease in corrosion current, ranging from 2.3 to 0.37 µA/cm2. Moreover, the MTT assay of the samples revealed that the amount of cell proliferation in the vicinity of the 48-hour extract of magnesium samples with double-layer coating had increased, indicating a decrease in the amount of ions released from the surface of magnesium by applying this coating.

Keywords

Main Subjects

References

[1]    J. Chen, Y. Yang, I. P. Etim, L. Tan, K. Yang, R. D. K. Misra, J. Wang, and X. Su, " Recent advances on development of hydroxyapatite coating on biodegradable magnesium alloys: a review", Materials, vol. 14, no. 19, pp. 5550, 2021.  https://doi.org/10.3390/ma14195550
[2]    L. Ling, S. Cai, Q. Li, J. Sun, X. Bao, and G. Xu, "Recent advances in hydrothermal modification of calcium phosphorus coating on magnesium alloy", Journal of Magnesium and Alloys, vol. 10, no. 1, pp. 62-80, 2021. https://doi.org/10.1016/j.jma.2021.05.014
[3]    V. Yadav, M. Sankar, and L. Pandey, "Coating of bioactive glass on magnesium alloys to improve its degradation behavior: Interfacial aspects", Journal of Magnesium and Alloys, vol. 8, no. 4, pp. 999-1051, 2020.https://doi.org/10.1016/j.jma.2020.05.005
[4]    R. Karunakaran, S. Ortgies, A. Tamayol, F. Bobaru, and M. P. Sealy, "Additive manufacturing of magnesium alloys", Bioactive Materials, vol. 5, no. 1, pp. 44-54, 2020. https://doi.org/10.1016/j.bioactmat.2019.12.004
[5]    B. R. Sunil, T. S. Kumar, U. Chakkingal, V. Nandakumar, M. Doble, V. Devi Prasad, and M. Raghunath, "In vitro and in vivo studies of biodegradable fine grained AZ31 magnesium alloy produced by equal channel angular pressing", Materials Science and Engineering: C, vol. 59, pp. 356-367, 2016. https://doi.org/10.1016/j.msec.2015.10.028
[6]    G. Song, "Control of biodegradation of biocompatable magnesium alloys", Corrosion Science, vol. 49, no. 4, pp. 1696-1701, 2007. https://doi.org/10.1016/j.corsci.2007.01.001
[7]    C. Blawert, W. Dietzel, E. Ghali, and G. Song, "Anodizing treatments for magnesium alloys and their effect on corrosion resistance in various environments", Advanced Engineering Materials, vol. 8, no. 6, pp. 511-533, 2006. https://doi.org/10.1002/adem.200500257
[8]    C. Wen, X. Zhan, X. Huang, F. Xu, L. Luo, and C. Xia, "Characterization and corrosion properties of hydroxyapatite/graphene oxide bio-composite coating on magnesium alloy by one-step micro-arc oxidation method", Surface and Coatings Technology, vol. 317, pp. 121-133, 2017. https://doi.org/10.1016/j.surfcoat.2017.03.034
[9]    H. Amiri, I. Mohammadi, and A. Afshar, "Electrophoretic deposition of nano-zirconia coating on AZ91D magnesium alloy for bio-corrosion control purposes", Surface and Coatings Technology, vol. 311, pp. 182-190, 2017. https://doi.org/10.1016/j.surfcoat.2016.12.103
[10] W. Liu, Z. Yan, Z. Zhang, Y. Zhang, G. Cai, and Z. Li, "Bioactive and anti-corrosive bio-MOF-1 coating on magnesium alloy for bone repair application", Journal of Alloys and Compounds, vol.788, pp. 705-711, 2019. https://doi.org/10.1016/j.jallcom.2019.02.281
[11] M. Razavi, M. Fathi, O. Savabi, S. M Razavi, B. H. Beni, D. Vashaee, and L. Tayebi, "Controlling the degradation rate of bioactive magnesium implants by electrophoretic deposition of akermanite coating", Ceramics International, vol. 40, no. 3, pp. 3865-3872, 2014. https://doi.org/10.1016/j.ceramint.2013.08.027
[12] H. Wang, C. Zhao, Y. Chen, J. Li, and X. Zhang, "Electrochemical property and in vitro degradation of DCPD–PCL composite coating on the biodegradable Mg–Zn alloy", Materials Letters, vol. 68, pp. 435-438, 2012. https://doi.org/10.1016/j.matlet.2011.11.029
[13] M. Tomozawa, S. Hiromoto, and Y. Harada, "Microstructure of hydroxyapatite-coated magnesium prepared in aqueous solution", Surface and Coatings Technology, vol. 204, no. 20, pp. 3243-3247, 2010.  https://doi.org/10.1016/j.surfcoat.2010.03.023
[14] A. Saberi, H.R. Bakhsheshi-Rad, S. Abazari, A.F. Ismail, S. Sharif, S. Ramakrishna, M. Daroonparvar, and F. Berto, "A comprehensive review on surface modifications of biodegradable magnesium-based implant alloy: Polymer coatings opportunities and challenges", Coatings, vol. 11, no. 7, pp. 747, 2021. https://doi.org/10.3390/coatings11070747
[15] S. M. Kim, M. H. Kang, H. E. Kim, H. K. Lim, S. H. Byun, J. H. Lee, and S. M. Lee, "Innovative micro-textured hydroxyapatite and poly (l-lactic)-acid polymer composite film as a flexible, corrosion resistant, biocompatible, and bioactive coating for Mg implants" , Materials Science and Engineering: C, vol. 81, pp. 97-103, 2017. https://doi.org/10.1016/j.msec.2017.07.026
[16] Y. F. Zheng, X. N. Gu, and F. Witte, "Biodegradable metals", Materials Science and Engineering: R: Reports, vol. 77, pp. 1-34, 2014. https://doi.org/10.1016/j.mser.2014.01.001
[17] L. Xu, and A. Yamamoto, "Characteristics and cytocompatibility of biodegradable polymer film on magnesium by spin coating", Colloids and Surfaces B: Biointerfaces, vol. 93, pp. 67-74, 2012. https://doi.org/10.1016/j.colsurfb.2011.12.009
[18] M. Diez, M. H. Kang, S. M. Kim, H. E. Kim, and J. Song, "Hydroxyapatite (HA)/poly-L-lactic acid (PLLA) dual coating on magnesium alloy under deformation for biomedical applications", Journal of Materials Science: Materials in Medicine, vol. 27, no. 34, 2016. https://doi.org/10.1007/s10856-015-5643-8
[19] H. Bakhsheshi-Rad, E. Hamzah, M. Abdul-Kadir, S. N. Saud, M. Kasiri-Asgarani, and R. Ebrahimi-Kahrizsangi, "The mechanical properties and corrosion behavior of double-layered nano hydroxyapatite-polymer coating on Mg-Ca alloy", Journal of Materials Engineering and Performance, vol. 24, pp. 4010-4021, 2015. https://doi.org/10.1007/s11665-015-1661-4
[20] M. S. Safavi, F. C. Walsh, M. A. Surmeneva, R. A. Surmenev, and J. Khalil-Allafi, "Electrodeposited hydroxyapatite-based biocoatings: Recent progress and future challenges", Coatings, vol. 11, no. 1, pp. 110, 2021.  https://doi.org/10.3390/coatings11010110
[21] D. Gopi, J. Indira, and L. Kavitha, "A comparative study on the direct and pulsed current electrodeposition of hydroxyapatite coatings on surgical grade stainless steel", Surface and Coatings Technology, vol. 206, no. 11-12, pp. 2859-2869, 2012. https://doi.org/10.1016/j.surfcoat.2011.12.011
[22] J. H. Park, Y. K. Lee, K. M. Kim, and K. N. Kim, "Bioactive calcium phosphate coating prepared on H2O2-treated titanium substrate by electrodeposition", Surface and Coatings Technology, vol. 195, no. 2-3, pp. 252-257, 2005. https://doi.org/10.1016/j.surfcoat.2004.08.185
[23] H. Bakhsheshi-Rad, E. Hamzah, A. Ismail, M. Aziz, M. Kasiri-Asgarani, E. Akbari, S. Jabbarzare, A. Najafinezhad, and Z. Hadisi, "Synthesis of a novel nanostructured zinc oxide/baghdadite coating on Mg alloy for biomedical application: In-vitro degradation behavior and antibacterial activities", Ceramics International, vol. 43, no. 17, pp. 14842-14850, 2017. https://doi.org/10.1016/j.ceramint.2017.07.233
[24] X. Gu, W. Zheng, Y. Cheng, and Y. F. Zheng, "A study on alkaline heat treated Mg–Ca alloy for the control of the biocorrosion rate", Acta Biomaterialia, vol. 5, no. 7, pp. 2790-2799, 2009. https://doi.org/10.1016/j.actbio.2009.01.048
[25] A. Nikbakht, C. Dehghanian, and R. Parichehr, "Silane coatings modified with hydroxyapatite nanoparticles to enhance the biocompatibility and corrosion resistance of a magnesium alloy", RSC Advances, vol. 11, no. 42, pp. 26127-26144, 2021. https://doi.org/10.1039/D1RA01018B
[26] L. Xu, F. Pan, G. Yu, L. Yang, E. Zhang, and K. Yang, "In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy", Biomaterials, vol. 30, no. 8, pp. 1512-1523, 2009. https://doi.org/10.1016/j.biomaterials.2008.12.001
[27] M. Rahman, N. K Dutta, and N. R. Choudhury, "Magnesium alloys with tunable interfaces as bone implant materials", Frontiers in Bioengineering and Biotechnology, vol. 8, 2020. https://doi.org/10.3389/fbioe.2020.00564
 
 
Send comment about this article
CAPTCHA Image

Files

Share

How to cite

Statistics