Bioactivity Comparison of Silk Fibroin/Nano-Titanium Dioxide and Silk Fibroin/Nano-Titanium Dioxide Containing Flour Ions for Bone Tissue Engineering

Document Type : Original Articles

Authors

• Narges Johari ¹
• Hamid Reza Madaah Hosseini ²
• Ali Samadikuchaksaraei ³

¹ Department of Materials Science and Engineering, Golpayegan University of Technology, Golpayegan, Iran.

² Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran.

³ Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.

10.22067/ma.v32i1.80791

Abstract

Bone defects and developed surgery with low injuries have conducted researches to design and produce composites containing biodegradable polymer and bioactive ceramic, introducing as a biocompatible scaffold for bone tissue engineering. In the present study, bioactive nanocomposite scaffolds of silk fibroin/titanium dioxide nanoparticles (SF/TiO₂) and silk fibroin/titanium dioxide nanoparticles which contain flour ions (SF/TiO₂-F) were prepared. Accordingly, flour ions were bound to TiO₂ nanoparticles and both SF/TiO₂ and SF/TiO₂-F scaffolds were produced. Then, the bioactivity and apatite formation on the surface of prepared scaffolds were evaluated by immersing in simulated body fluid (SBF) for 28 days. As a resultant, SF/TiO₂-F scaffolds showed improved bioactivity in comparison with SF/TiO₂ ones, as such, after 12 days of immersion in SBF, apatite precipitations covered around 40 %  of surface of prepared scaffolds. 

Keywords

• Bioactive scaffold
• Fibroin
• Titanium dioxide nanoparticles
• Flour ion

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