ارزیابی کریستالی و فازی هیدروکسی آپاتیت سنتز شده به طریق سل-ژل با نسبت های مختلف Ca/P

نوع مقاله : علمی و پژوهشی

نویسندگان

1 یزد

2 دانشگاه علم و صنعت ایران

چکیده

در این مطالعه با استفاده از مواد اولیه پنتا اکسید فسفر (P2O5) و کلسیم نیترات چهار آبه (Ca(NO3)2.4H2O) و به کارگیری روش سل –ژل سنتز پودر هیدروکسی آپاتیت با سه نسبت مولی متفاوت کلسیم به فسفر (Ca/P) معادل 6/1، 5/1 و 67/1 انجام گرفته است. نتایج پراش پرتوی اشعه ایکس (XRD) نشان می دهد که بالاترین شدت قله پراش برای فازهای هیدروکسی آپاتیت و بتا-تری کلسیم فسفات -TCP متعلق به پودر سنتز شده با نسبت 6/1Ca/P = می باشد. وجود این دو فاز به طور همزمان در پودر سنتز شده باعث شده تا یک بیوسرامیک دو فازی با قابلیت استخوان سازی مناسب ایجاد شود. با عملیات حرارتی در دمای 1100 درجه سانتی گراد، شدت قله های پراش فاز-تری کلسیم فسفات (Ca3(PO4)2) در هر سه نمونه افزایش یافته و از شدت قله های پراش هیدروکسی آپاتیت کاسته می شود به طوری که برای نمونه با 5/1=Ca/P، فاز غالب -تری کلسیم فسفات خواهد بود. نتایج مشاهدات میکروسکوپ الکترونی روبشی (SEM)در بزرگنمایی بالا بخوبی ذرات نانو هیدروکسی آپاتیت در مقیاس 10 الی 400 نانومتر را نشان داده و در بزرگنمایی پایین خوشه هایی از نانو ذرات مشاهده می شود. نتایج مطالعات ارزیابی زیست فعالی نشان می دهد که با افزایش نسبت Ca/P، میزان آپاتیت تشکیل شده روی سطح افزایش می یابد که نتیجه آن زیست فعالی بالاتر بیومتریال می باشد.

کلیدواژه‌ها

عنوان مقاله [English]

Crystal and Phase Evolution of Sol-Gel Derived Hydroxyapatite Synthesis with Various Ca/P Ratios

نویسندگان [English]

  • mahdi kalantar 1
  • maryam mojahedian 1
  • narges N. Vahidi 2
1 Yazd University
2 Iran University of Science and Technology
چکیده [English]

Hydroxyapatite due to its biocompatibility and chemical and biological affinity with bone tissue is used for orthopedic implant, dental implant, oral and maxillofacial surgery and as a coating film on metal or alloy implants. In this study, hydroxyapatite powders were synthesized with three different ratios of Ca/P = 1.6, Ca/P = 1.5 and Ca/P = 1.67 using sol-gel method and utilizing P2O5 and Ca(NO3)2.4H2O as starting materials. The X-ray diffraction (XRD) results reveal that the highest peak of hydroxyapatite and -TCP, a biphasic bioceramic with high ability of ossification, are found for the hydroxyapatite powder synthesized with Ca/P=1.6. Microstructural studies at high magnifications reveal a uniform distribution of hydroxyapatite nanoparticles (10-400 nm) while at low magnifications only clusters of nano-particles could be detected. The peak intensity of the TCP phase is increased after applying the sintering heat treatment for all three ratios of Ca/P. By increasing the Ca/P ratio from 1.5 to 1.6, the grain size of the sintered samples increased and the morphology of the microstructure became coarser. The biocompatibility evaluation of the synthesized hydroxyapatite indicate that increasing the ratio of Ca/P will increase the volume and rate of apatite formation on the surface of the sintered samples.

کلیدواژه‌ها [English]

  • Hydroxyapatite
  • Sol-gel
  • Calcination, phase analysis
  • Microstructure
  • Sintering
  • Bioactivity

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