ایجاد پوشش دولایه‏ nHydroxyapatite/Poly(lactic-co-glycolic)acid بر منیزیم و بررسی خواص خوردگی و زیست‎‏سازگاری

نوع مقاله : علمی و پژوهشی

نویسندگان

ندا عبودزاده

مینا محمدی زاده

علیرضا خاوندی

علیرضا ایوانی

دانشکده مهندسی مواد و متالورژی، دانشگاه علم و صنعت ایران، تهران، ایران

10.22067/jmme.2024.83920.1121

چکیده

در این تحقیق با هدف کنترل خوردگی و امکان کاربرد کلینیکی منیزیم، پوشش دولایه هیدروکسی ‏آپاتیت -پلی ‏لاکتیک‏ گلیکو لیک ‏اسید به ترتیب با روش‌های رسوب دهی الکتریکی و غوطه وری بر نمونه منیزیمی اعمال گردید. مشخصه ‏یابی پوشش‌ها با کمک پراش پرتو ایکس و میکروسکوپ الکترونی روبشی، نشان دهنده تشکیل یکنواخت پوشش ها با ضخامت µm 30 – 20 بر سطح منیزیم است. آزمون‏ الکتروشیمیایی پلاریزاسیون تافل بر نمونه‌ها نشان داد که با اعمال پوشش دو لایه هیدروکسی ‏آپاتیت- پلی ‏لاکتیک ‏گلایکولیک ‏اسید بر منیزیم، پتانسیل خوردگی از V 82/1- به V 4/1- افزایش و چگالی جریان خوردگی از µA/cm2 3/2 به µA/cm2 37/0 کاهش می‏ یابد. نتایج آزمون MTT نیز نشان داد که مقدار تکثیر سلولی در مجاورت عصاره 48 ساعته نمونه‏ های منیزیمی با پوشش دو لایه بیشتر شده است، که حکایت از کاهش مقدار یون آزاد شده از سطح منیزیم با کمک اعمال این پوشش ها است.

کلیدواژه‌ها

منیزیم

هیدروکسی&rlm

آپاتیت

پلی&rlm

لاکتیک&rlm

گلایکولیک&rlm

اسید

زیست&rlm

سازگاری

خوردگی

موضوعات

• بیو مواد

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عنوان مقاله English

Preparation of a Bilayer Coating of nHydroxyapatite/Poly(lactic-co-glycolic)acid on Mg and Investigation of Corrosion Properties and Biocompatibility

نویسندگان English

Neda Aboudzadeh

Mina Mohamadizadeh

Alireza Khavandi

alireza eivani

School of Metallurgy and Materials Engineering, Iran University of science and Technology, Tehran, Iran.

چکیده English

In this study, intending to control the corrosion of magnesium and its clinical application, a double-layer coating of Hydroxyapatite- Poly lactic-co-glycolic acid was applied on Mg by means of the electrodeposition and the dip method, respectively. X-ray diffraction (XRD) and scanning electron microscopy (SEM) are used to characterize the phase and morphology of the coatings. The results show a homogeneous coating with a thickness of 20-30 µm. Potentiodynamic polarization of the samples revealed that the double-layer coating exhibited a significant increase in corrosion potential, ranging from -1.82 to -1.4 V, and a decrease in corrosion current, ranging from 2.3 to 0.37 µA/cm2. Moreover, the MTT assay of the samples revealed that the amount of cell proliferation in the vicinity of the 48-hour extract of magnesium samples with double-layer coating had increased, indicating a decrease in the amount of ions released from the surface of magnesium by applying this coating.

کلیدواژه‌ها English

Magnesium

Hydroxyapatite

Poly lactic-co-glycolic acid

Double-layer coating

Corrosion

Biocompatibility

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