بهینه سازی پارامترهای مؤثر بر فرآیند تولید داربست مهندسی بافت نانوبیوکامپوزیتی پلی لاکتیک گلیکولیک اسید/ کیتوزان

نوع مقاله : علمی و پژوهشی

نویسندگان

1 دانشگاه پیام نور مرکز اصفهان

2 دانشگاه صنعتی اصفهان

چکیده

علم بین رشته‌ای مهندسی بافت، سلول‌های ناحیه‌ای از بدن یا سلول‌های بنیادی در محیط خارج بدن را کشت داده، مجتمع سلولی رشد و تمایزیافته را بر روی بسترهای بیومتریالی نشانده و وارد بدن فرد بیمار می‌کنند. پلی‌لاکتیک‌گلیکولیک‌اسید و کیتوزان به‌ترتیب از دسته‌ی پلیمرهای مصنوعی و طبیعی متداول برای کاربردهای مهندسی بافت هستند. در این پژوهش با استفاده از روش الکتروریسی/الکترواسپری همزمان، داربست مهندسی بافت نانوبیوکامپوزیتی تهیه شد. در این تحقیق الیافی با آرایش تصادفی و هم‌راستا تهیه شد و مورفولوژی و میانگین اندازه ذرات و میانگین قطر الیاف به روش آنالیز با نرم افزار مورد ارزیابی قرار گرفت

کلیدواژه‌ها


عنوان مقاله [English]

Optimization of Process Parameters of PLGA/CS Nano-bio-camposite as Tissue Engineering Scaffold

نویسندگان [English]

  • Sedigheh Vaezifar 1
  • Elham Halvani-Anaraki 2
1 Payame Noor University, I.R. Iran
2 IsfahanUniversity of Technology
چکیده [English]

Tissue engineering, as an interdisciplinary science, is culturing cell body or stem cells outside the body and depositing grown and differentiated cell complex on substrate biomaterials into a patient's body. PLGA and chitosan are commonly used for tissue engineering applications, respectively as synthetic and natural polymers. In this study, nano-biocomposite scaffold of tissue engineering was prepared by electrospinning/electrospraying method. Nanofibers with random and aligned arrangement were prepared. The average particle size and fiber diameter was measured using Image J analysis software.

کلیدواژه‌ها [English]

  • Electrospraying
  • Electrospinning
  • PLGA
  • scaffold
  • Chitosan Nanoparticles
  • tissue engineering
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